Good Quality Pharmaceutical Raw Material Tacrolimus CAS 104987-11-3

Model NO.: 104987-11-3
CAS: 104987-11-3
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 2937290090
Model NO.: 104987-11-3
CAS: 104987-11-3
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 2937290090
Basic info.

Tacrolimus
Purity: 99%
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Melting Point: 113-115° C
Boiling Point: 871.7 ° C at 760 mmHg
Appearance: White powder
Lead time: 1-2 days upon receipt of payment
Delivery time: Usually 4-6 working days by air
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
 

Description
 
1. Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response.
 
2. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 
3. Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 

Good Quality Pharmaceutical Raw Material Tacrolimus CAS 104987-11-3


Application

L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
 

 

Mechanism of action
Tacrolimus,The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
 
Tacrolimus,A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
 
Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

 

Our advantage

1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.



Tacrolimus COA
 
Product Name Tacrolimus Batch No. YC171103
Quantity 50g/bag MFG. Date April.1.2016
Exp. Date July.31.2019 CAS No. 104987-11-3
ITEMS SPECIFICATIONS RESULTS
description a white to off-white powder white powder
by IR spectroscopy IR spectrum of sample should match with standard IR spectrum conforms
HPLC the retention time of the major peak of the sample solution corresponds to that of the standard solution as obtained in the assay coforms
loss on drying not more than 4.0% 2.2%
residue on ignition Not more than 0.2% 0.04%
heavy metals not more than 20ppm less than 20ppm

specific optical rotaion
-80 °  to -90 °  -89 ° 
any individual impurity not more than 0.5% 0.08%
total impurity not more than 1.0% 0.25%
assay by HPLC 98.0%-102.0% 99.0%
CONCLUSION Qualified



FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.

We specialized in manufacturing high quality and reliable raw material 
which are widely used in the fields of food, health, cosmetics, pharmaceuticals, and Bodybuilding
 
we have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.



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If you want to know more about our products,please search
Zoey Li


 http://www.slsteroid.com
 
XiamenShengLangSaiChuangBiologicalTechnologyCo.,Ltd
 

Good Quality Pharmaceutical Raw Material Tacrolimus CAS 104987-11-3



  Basic info.

Tacrolimus
Purity: 99%
CAS: 104987-11-3
MF: C44H69NO12
MW: 804.02
Melting Point: 113-115° C
Boiling Point: 871.7 ° C at 760 mmHg
Appearance: White powder
Lead time: 1-2 days upon receipt of payment
Delivery time: Usually 4-6 working days by air
Storage: Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
 

Description
 
1. Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response.
 
2. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 
3. Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 

Good Quality Pharmaceutical Raw Material Tacrolimus CAS 104987-11-3


Application

L Immunosuppression following transplantation It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
 

 

Mechanism of action
Tacrolimus,The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
 
Tacrolimus,A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
 
Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

 

Our advantage

1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.



Tacrolimus COA
 
Product Name Tacrolimus Batch No. YC171103
Quantity 50g/bag MFG. Date April.1.2016
Exp. Date July.31.2019 CAS No. 104987-11-3
ITEMS SPECIFICATIONS RESULTS
description a white to off-white powder white powder
by IR spectroscopy IR spectrum of sample should match with standard IR spectrum conforms
HPLC the retention time of the major peak of the sample solution corresponds to that of the standard solution as obtained in the assay coforms
loss on drying not more than 4.0% 2.2%
residue on ignition Not more than 0.2% 0.04%
heavy metals not more than 20ppm less than 20ppm

specific optical rotaion
-80 °  to -90 °  -89 ° 
any individual impurity not more than 0.5% 0.08%
total impurity not more than 1.0% 0.25%
assay by HPLC 98.0%-102.0% 99.0%
CONCLUSION Qualified



FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.

We specialized in manufacturing high quality and reliable raw material 
which are widely used in the fields of food, health, cosmetics, pharmaceuticals, and Bodybuilding
 
we have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.



More Hot Sale Products:
Mirtazapine 85650-52-8
Trazodone Hydrochloride 25332-39-2
Phenibut 1078-21-3
Tianeptine Sodium 30123-17-2
NSI-189 Phophate 1270138-41-4
5-Hydroxytryptophan 4350/9/8
Sunifiram 314728-85-3
   
Armodafinil 112111-43-0
CRL-40,940 90280-13-0
Zopiclone  43200-81-3
Ginkgo biloba /
Huperzine A 120786-18-7
CDP-Choline/Citicoline 987-78-0
Bacopa Monnieri  93164-89-7
Phosphatidylserine 51446-62-9
N-Methyl-D-Aspartic Acid/NMDA 6384-92-5
Memantine HCL 3717-88-2
Duloxetine Hydrochloride 136434-34-9
Semax 80714-61-0
Rivastigmine Tartrate 129101-54-8
Galantamine 357-70-0
Citicoline Sodium 33818-15-4
Nefiracetam 77191-36-7
Picamilon Na+ 62936-56-5
   
Choline Bitartrate 87-67-2
Choline Glycerophosphate/Alpha GPC 28319-77-9
Resveratrol 501-36-0
Melatonine 73-31-4
Noopept 157115-85-0
N, N-Dimethyl-2-Phenylethylamine HCL 10275-21-5
Fasoracetam 110958-19-5
PRL-8-53 HCL 51352-87-5
Unifiram 272786-64-8
Centrophenoxine 3685-84-5
Sunifiram 314728-85-3
Piracetam 7491-74-9
Pramiracetam 68497-62-1
Aniracetam 72432-10-1
Coluracetam/MKC-231 135463-81-9
PRL-8-53 HCL 51352-87-5
Bisibutiamine 3286-46-2
4-Aminobutyric acid/GABA  1959/12/1
Pterostilbene 537-42-8
Ubidecarenone/Coenzyme Q10/Coq10 303-98-0
Vinpocetine 42971-09-5
Oxiracetam 62613-82-5
Idebenone 58186-27-9
9-Fluorenol/Hydrafinil 1689-64-1
DMAE 5988-51-2


If you want to know more about our products,please search
Zoey Li


 http://www.slsteroid.com
 
XiamenShengLangSaiChuangBiologicalTechnologyCo.,Ltd
 

Good Quality Pharmaceutical Raw Material Tacrolimus CAS 104987-11-3