High Quality Anti-Tumor Raw Powder Pomalidomide CAS: 19171-19-8

Model NO.: CAS NO: 19171-19-8
Appearance: White Powder
Purity: 99%
Storage Conditions: 2-8°c
Density: 1.57g/cm3
Trademark: NJBN
Transport Package: 1kg/Foil Bag; 25kg/Drum
Specification: 1kg/foil bag; 25kg/drum
Origin: China
HS Code: 3001200010
Model NO.: CAS NO: 19171-19-8
Appearance: White Powder
Purity: 99%
Storage Conditions: 2-8°c
Density: 1.57g/cm3
Trademark: NJBN
Transport Package: 1kg/Foil Bag; 25kg/Drum
Specification: 1kg/foil bag; 25kg/drum
Origin: China
HS Code: 3001200010
High Quality Anti-tumor Raw Powder Pomalidomide CAS: 19171-19-8

Quick Details of Pomalidomide:
 
Product Name Pomalidomide
Synonyms 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide;4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;Pomalidomide;Pomalidomide(CC-4047);ActiMid;CC-4047;4-AMino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;
CAS No. 19171-19-8
Molecular Formula C13H11N3O4
Molecular Weight 273.24
EINECS No. 1592732-453-0
Melting point 318.5 - 320.5 ºC
Boiling point 582.9ºC at 760mmHg
Flash point 306.3ºC
Density 1.57g/cm3
Solubility DMSO: ≥14mg/mL
Refractive index 1.691
Appearance White Powder
Purity 99%
Quality Standard Enterprise standard
Storage Conditions 2-8°C
Packing 1kg/foil bag;25kg/drum
Shipment EMS;DHL;FedEx;TNT;UPS
Delivery Time 3-5 Working Days
Payment terms T/T;Western Union;Money Gram;Bitcoin
Usage Treatment of patients with multiple myeloma after treatment with other anticancer drugs continues to progress.

High Quality Anti-Tumor Raw Powder Pomalidomide CAS: 19171-19-8


Pomalidomide Descriptions:

Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.

Pomalidomide In vitro studies:

Pomalidomide inhibits the release of TNF-alpha stimulated by lipopolysaccharide (LPS) and has an IC50 of 13 nM and 25 nM in human PBMC and human whole blood, respectively. Pomalidomide inhibits IL-2-stimulated T regulatory cells with IC50 of ~1 μM. 6.4 nM-10 μM Pomalidomide treats human peripheral blood T cells and increases IL-2 production, acting on the CD4+ subset more efficiently than on the CD8+ subset. Pomalidomide significantly promotes IL-2, IL-5, and IL-10 than CC-5013, and slightly promotes IFN-γ over CC-5013. Pomalidomide acts on Jurkat cells and enhances AP-1 and Raji cell-induced AP-1 transcriptional activity, which is the highest 4-fold increase at 1 μM. This effect is dose-dependent. Raji cells treated with different concentrations of Pomalidomide (2.5-40 μg/mL) for 48 hours resulted in a significant decrease in cell proliferation and DNA synthesis, which was reduced by ~40% compared to the control group.

Pomalidomide In vivo studies:

Pomalidomide acts on SCID mice and enhances the anticancer effect of Rituximab on B-cell lymphoma. The combination of pomalidomide and Rituximab resulted in an average life span of 74 days, and the average life span of mice treated with CC5013/Rituximab was 58 days. Depletion of NK cells results in the complete abolition of the synergistic effects of Pomolidomide and Rituximab, suggesting that NK cell proliferation is a mechanism by which Pomalidomide enhances Rituximab's anticancer activity.

Our order process:
Step 1 Please tell me in what products you are interested including CAS number, quantities, and the destination country.
Step 2 You confirm all details and offer us purchase order.
Step 3 We offer the quotation of products and suitable shipping method for reference.
Step 4 You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc.
Step 5 We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h
Step 6 We offer after-sales service after you receive products.

Our competitive advantages:
Rich experience Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Wide range of export Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
High customs pass guaranteed Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
Fast leading time Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc
High Quality Anti-tumor Raw Powder Pomalidomide CAS: 19171-19-8

Quick Details of Pomalidomide:
 
Product Name Pomalidomide
Synonyms 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide;4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;Pomalidomide;Pomalidomide(CC-4047);ActiMid;CC-4047;4-AMino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;
CAS No. 19171-19-8
Molecular Formula C13H11N3O4
Molecular Weight 273.24
EINECS No. 1592732-453-0
Melting point 318.5 - 320.5 ºC
Boiling point 582.9ºC at 760mmHg
Flash point 306.3ºC
Density 1.57g/cm3
Solubility DMSO: ≥14mg/mL
Refractive index 1.691
Appearance White Powder
Purity 99%
Quality Standard Enterprise standard
Storage Conditions 2-8°C
Packing 1kg/foil bag;25kg/drum
Shipment EMS;DHL;FedEx;TNT;UPS
Delivery Time 3-5 Working Days
Payment terms T/T;Western Union;Money Gram;Bitcoin
Usage Treatment of patients with multiple myeloma after treatment with other anticancer drugs continues to progress.

High Quality Anti-Tumor Raw Powder Pomalidomide CAS: 19171-19-8


Pomalidomide Descriptions:

Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.

Pomalidomide In vitro studies:

Pomalidomide inhibits the release of TNF-alpha stimulated by lipopolysaccharide (LPS) and has an IC50 of 13 nM and 25 nM in human PBMC and human whole blood, respectively. Pomalidomide inhibits IL-2-stimulated T regulatory cells with IC50 of ~1 μM. 6.4 nM-10 μM Pomalidomide treats human peripheral blood T cells and increases IL-2 production, acting on the CD4+ subset more efficiently than on the CD8+ subset. Pomalidomide significantly promotes IL-2, IL-5, and IL-10 than CC-5013, and slightly promotes IFN-γ over CC-5013. Pomalidomide acts on Jurkat cells and enhances AP-1 and Raji cell-induced AP-1 transcriptional activity, which is the highest 4-fold increase at 1 μM. This effect is dose-dependent. Raji cells treated with different concentrations of Pomalidomide (2.5-40 μg/mL) for 48 hours resulted in a significant decrease in cell proliferation and DNA synthesis, which was reduced by ~40% compared to the control group.

Pomalidomide In vivo studies:

Pomalidomide acts on SCID mice and enhances the anticancer effect of Rituximab on B-cell lymphoma. The combination of pomalidomide and Rituximab resulted in an average life span of 74 days, and the average life span of mice treated with CC5013/Rituximab was 58 days. Depletion of NK cells results in the complete abolition of the synergistic effects of Pomolidomide and Rituximab, suggesting that NK cell proliferation is a mechanism by which Pomalidomide enhances Rituximab's anticancer activity.

Our order process:
Step 1 Please tell me in what products you are interested including CAS number, quantities, and the destination country.
Step 2 You confirm all details and offer us purchase order.
Step 3 We offer the quotation of products and suitable shipping method for reference.
Step 4 You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc.
Step 5 We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h
Step 6 We offer after-sales service after you receive products.

Our competitive advantages:
Rich experience Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Wide range of export Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
High customs pass guaranteed Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
Fast leading time Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc