Pharmaceutical Intermediates for Body-Building Trilostane for Breast Cancer Treatment / CAS 13647-35-3

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  • Powder: Yes
  • Certification: GMP, ISO 9001, USP
  • State: Solid
  • Trademark: LvXin
  • Specification: 10g, 50g, 100g, 1kg
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Transport Package: According The Quantity
  • Origin: China

Product Description
Anti Estrogen Steroids  / Trilostane (99%) for Breast Cancer Treatment  / CAS 13647-35-3


Quick Detail:

Trilostane
Synonym: Vetoryl
CAS Registry Number: 13647-35-3
Alias: 99%
Einecs No: 237-133-0
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Manufacturer: Yuan Cheng
Molecular Weight: 329.4333
Molecular Formula: C20H27NO3
Melting point: 264° C
Boiling point: 497.8° C at 760 mmHg
Refractive index: 1.61
Flash point: 254.8° C
Vapour Pressur: 5.39E-12mmHg at 25° C
Lead time: 1-2 days upon receipt of payment
Delivery Term: Products below 200Kg by air; Over 200Kg by ship
Delivery Time: Average 6 days by air; 15 days by ship
Usage: Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, 
make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome
 (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum 
testosterone level.
 
 
Description

Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase,
 which plays a role in adrenal steroid biosynthesis. Investigators believe 
that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 
3β-HSD, but not 
3βHSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular
 production oin LNCaPFGC prostate cancer cells and inhibiting cortisol biosynthesis in the human 
adrenal gland. This product serves as a useful tool in steroid biosynthesis research.


Uses:

Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, 
aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase 
disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product 
has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic.



Specification:
 

Test  Item
Analysis  Specification
Result

Description
White to off-white power
Conforms

Purity
98.5%min
99.20%

Water(K.F)
≤0.5%
0.20%

Loss on drying
≤0.5%
0.26%

Residue on ignition
≤0.1%
0.04%

Heavy metals
≤20ppm
<20ppm

Specific optional rotation
+137°~ +139°
+138.8°

Conclusion
Conform to Company Standard.

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