Limiting heat slows the biological "clock" operation
September 21, 2017 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; A mouse and primate research paper published by the British journal Nature Communications on the 17th suggested that calorie restriction can slow down the "episogenetic clock." Previously, scientists have studied worms, mice, and primates and concluded that caloric restriction can extend lifespan, while new research links life to the epigenetic clock and shows that the "clock" is a study. An important biomarker of aging.
If our genome is a list of all genes in the body, epigenetic markers (such as methylation) are a series of DNA-related instructions for how to "read correctly" the gene. Previous studies have shown that DNA methylation in cells changes over time and can be used as a biomarker for each cell age, like an epigenetic clock. Known cancers and neurodegenerative diseases, etc., are associated with an increase in the epigenetic age of diseased tissues.
This time, in order to study the relationship between epigenetic clock and longevity, a team of researchers at Temple University in the United States compared DNA methylation patterns in mice, primates and humans of different ages and found that The speed at which the genetic clock operates is also related to life. In mammals with short life spans, such as mice, epigenetic markers of cells change faster than mammals that live longer (such as humans).
Next, the team measured the rate of epigenetic senescence in mice and primates whose diet was strictly controlled, and found that the epigenetic aging rate of caloric-restricted animals was slower than that of the control animals.
This study demonstrates that epigenetic aging rates determine the lifespan of mammals. In addition, it provides evidence to support the value of the "epigenical clock" as an important marker of biological aging.
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