The molecular mechanism of environmental stress leading to depression is revealed by the treatment of inhibition. There are new intervention targets.
January 8, 2019 Source: Health News Author: Fu Hung Dong Song scholarly
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The team of researchers of Huang Zhuo, State Key Laboratory of Natural Medicines and Biomimetic Drugs, and the research group of Associate Professor Liang Jing of Peking University School of Medicine, recently published a paper published online in the internationally renowned psychiatric journal Biopsychiatry. In the social frustration depression model, the role of forebrain histone crotonylation modification and epigenetic molecule CDYL in the occurrence and development of depression and its molecular mechanism provide a new theoretical basis for the development of depression, which is an inhibitory disease. Treatment provides a potential intervention target.
According to Huang Zhuo, depression is a common mental illness in modern society, affecting the normal life of more than 300 million people. The occurrence of depression is not only regulated by genetics, but also closely related to environmental stress such as stress and traumatic memory. However, the molecular mechanism of environmental stress leading to depression is still unclear. The research team focused on the epigenetic changes in the brain caused by environmental stress, with the epigenetic factor CDYL-regulated histone crotonylation modification (referring to the introduction of crotonyl groups on histone lysine residues) as a cut-in Point, the study of the pathogenesis of depression caused by stress.
The researchers found that the expression of a histone crotonyl hydrolase and transcriptional repressor CDYL in the anterior cortex (PL) of depressed mice increased significantly, and the level of histone crotonylation was significantly decreased. When PL overexpresses CDYL, it can increase the susceptibility of mice to depression. Conversely, knocking down CDYL can reduce the susceptibility of mice to depression. The researchers also found that CDYL can regulate the synaptic plasticity by inhibiting the expression of neuropeptide VGF, thereby regulating the development of stress-mediated depression. This study first reported the role of histone crotonylation in depression and linked the environmental stress to the pathogenesis of depression.
Losing Weight Plant Extract,Senna Leaf Extract,Bulk Senna Leaf Extract,Senna Leaf Extract Powder
Youth Biotech CO,. Ltd. , https://www.youtherb.com