Pharmacological effects
Review
1 Effect on the central nervous system: Gentiana neutral oils were intragastrically administered with a 1/10, 1/5 median lethal dose (70.17±4.95 g (crude drug)/kg). Spontaneous activity of mice against exercise amphetamine-induced excitement, enhanced hypnotic effect of thiopental against writhing caused by strontium potassium tartrate, prolonged hot plate reaction time, decreased body temperature of experimental febrile rabbits and body temperature of normal mice.
2Anti-inflammation: 1/10, 1/5 median lethal dose (primary lethal dose ibid) of neutral oil in gizzards was intragastrically administered to inhibit xylene-induced mouse ear swelling; and carrageenan-induced rat paw was inhibited swelling.
3 Effects on intestinal and uterine smooth muscles: Sakamoto neutral oil 1.4×10-3-5.6×10-3g/ml can inhibit the contraction of isolated intestine in rabbits and guinea pigs, and can fight against histamine, acetylcholine, nicotine, and toxicity. The effects of physostigmine, phentolamine, and barium chloride on the contraction of bowel; 70, 140 g/kg gavage, inhibition of mouse small intestine advancing exercise, and inhibition of castor oil-induced diarrhea in mice; 7×10-3-14×10- 3g/ml inhibited the isolated uterus of the rabbit, and it was able to resist the effect of oxytocin on the uterus.
Antimicrobial effect
The 15% decoction was diluted with a plate to inhibit the dermatophytes such as Trichoderma lucidum.
Sedation, analgesia, antipyretic and anti-inflammatory effects
2.1. Sakamoto neutral oil can inhibit the spontaneous activity of mice and combat amphetamine-induced exercise excitement, can enhance the hypnotic effect of thionin, can resist the mice twist reaction caused by potassium antimony tartrate and significantly prolong the hot plate reaction. Time, and reduce the body temperature of fever animals and body temperature of normal mice, but also against xylene inflammation.
2.2. Sakamoto neutral oil can inhibit acetic acid to increase capillary permeability in the abdominal cavity of mice, histamine increases rat skin capillary permeability, inhibits xylene-induced ear shell swelling, and inhibits carrageenan-induced rat paws. Swelling and removal of paw swelling caused by adrenal rat injection of carrageenan. However, it can not inhibit the plastic ring granuloma hyperplasia in rats, nor can it extend the survival time of adrenal gland rats. It is suggested that the anti-inflammatory effect is not related to the pituitary-adrenal system. It is speculated that it may be produced by inhibiting prostaglandins to produce anti-inflammatory effects.
2.3. Ferulic acid, one of the ingredients in the quail, can reduce the twisting reaction and prolong the sleeping time of cyclohexene pentobarbital. In addition, the other ingredient ligustilide has sedation, hypnosis, cooling and anti-ketamine excitement. .
Smooth muscle effect
3.1. Intestinal and uterine smooth muscle inhibitory effects: Sakamoto neutral oil can inhibit isolated rabbit intestinal contraction amplitude, inhibit guinea pig ileum tension, inhibit the role of isolated rabbit uterine tension; can also fight histamine, acetylcholine, nicotine, The activity of bowel activity caused by physostigmine, phentolamine, and barium chloride stimulates the uterine muscle tone increase induced by oxytocin; it also inhibits the mice's small intestine advancing exercise and inhibits castor oil-induced diarrhea in mice. The results showed that Sakamoto neutral oil has the effect of inhibiting intestinal and uterine smooth muscle.
Antiasthmatic effect
3.2.1. Anti-asthmatic effect of genistein: Intraperitoneal injection of 0.14 ml/kg ligustilide to guinea pigs can relieve the asthma-related reaction caused by histamine and acetylcholine, and its efficacy is similar to aminophylline 50 mg/kg in guinea pigs. Pulmonary overflow experiment, intravenous injection of ligustilide 0.08ml/kg against histamine 2-10μg/kg caused by bronchoconstriction. Ligustilide not only has relaxing effect on isolated tracheal strips in guinea pigs, but also has obvious antispasmodic effect on smooth muscle contractions of trachea caused by acetylcholine, histamine and barium chloride. This effect cannot be blocked by propranolol. Ligustilide had no significant effect on cAMP and cGMP levels in the lungs and intestine of guinea pigs and it is thought that it may act on smooth muscle itself.
3.2.2. Antiasthmatic effect of benzoquinone and its derivatives: benzoquinone and its derivatives vinyllactone, propenyl lactone, n-butyrolactone and n-butyl-fleurolactone have remarkable effects on the tracheal smooth muscle of animals. The relaxing effect. There was no significant difference in the strength of action. It was considered that the anti-asthmatic effect of n-butyrolactone and its homologues was attributed to its parent phenylhydrazone. There appeared to be a regular change in the speed of action and chemical structure of the six compounds. Among them, quinones and vinyllactones are the fastest, and they tend to slow down with the growth of side chains. N-butylflavone without a double bond has a faster action than n-butyrolactone with a double bond. The effect of phenylephrine-relaxed tracheal smooth muscle is not caused by excitation of the β-receptors in the smooth muscles of the trachea or the release of mediators that promote adrenergic nerve release. It has little to do with M-choline receptors and histamine receptors. Benzoquinone can quickly and significantly counteract the effect of lanthanum chloride, suggesting that it may be a direct effect of relaxation of tracheal smooth muscle. The above compounds all have certain toxicity and irritating effects on the gastrointestinal tract.
[concocted]: remove the residual stem, pick the net impurities, wash, run through slices dried.
The original state of the plant
The original state of the plant
ã€Taste】: Sim, warm.
1 "The Classic": "Sin, Wen."
2 "Theory of Pharmacy": "Dark temperature."
3 "Materia Medica": "Sweet and sweet, warm in nature."
[]: After the bladder into the bladder.
1 "Pearl Capsule": "The bladder of the sun and the solar small intestine of the hand."
2 "Bencai seeking truth": "Into the bladder, and into the strange Governor."
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