Release date: 2014-10-15
Recently, the Department of Orthopaedics of the Southwest Hospital of the Third Military Medical University has succeeded in the development of allogeneic bone transplantation in China. Highly active allogeneic bone has been able to partially replace human autologous bone function. Please pay attention - can allogeneic bone transplantation be fully promoted?
Recently, the first full-transplant allogeneic bone in the Department of Orthopaedics, Southwest Hospital of the Third Military Medical University has been successfully recovered. The allogeneic bone transplanted into the patient has been in good condition for a year. "From the current point of view, the high-activity tissue-engineered bone made with the bone growth accumulator is more suitable for clinical use than the artificial bone with poor activity before." Professor Xu Jianzhong, the director of the department, said that with clinical application and research Development, a new generation of high-activity allogeneic bone is expected to be fully promoted, patients who are in urgent need of bone transplantation will have safer and more effective treatment options.
Domestically successful first allogeneic bone implant surgery
At the beginning of 2013, a 9-year-old child from Dazhou, Sichuan Province experienced a serious car accident, causing severe fractures of his lower extremities, extensive muscle tears, and hemorrhagic shock. The left lower extremity was severely damaged. He had to undergo bone transplantation before he was expected to resume walking. ability. After being rescued by the local hospital, he was transferred to the Department of Orthopaedics of the Southwest Hospital for treatment.
According to reports, due to children's development problems, the amount of autologous bone is limited, the conventional use of bone grafting method is not suitable for this patient. After detailed demonstration and surgical design, in August 2013, the Department of Orthopaedics of Southwest Hospital successfully completed the repair of the bone defect site with high-activity allogeneic bone material. This is also the first bone marrow harvesting allogeneic bone graft operation in China. After one year of observation, the patient recovered well and the allogeneic bone grew normally in the body.
Currently, autologous bone remains the most suitable material in the bone graft materials available. However, autologous bone is limited by age, bone volume, etc., and complications such as pain and infection in the bone area are more common, and it is not necessarily the best choice for patients. "From 863 scientific research project "Development of Tissue Engineering Bone" since 2006, one of the branches has how to improve the growth activity of allogeneic bone in the human body." Xu Jianzhong said that many experts in orthopedics have a great understanding of the development of tissue engineering bone. Great interest. But for a long time, almost all synthetic bone graft materials lack the necessary biologically active osteogenic components.
More than 100 allogeneic bone implant patients have good postoperative results
According to reports, many international studies have shown that autologous red bone marrow is rich in a large number of hematopoietic stem cells and a variety of osteogenic growth factors. In view of the insufficient activity of bone graft materials, the Southwest University Hospital orthopedic research team envisioned the design of “bone growth enrichment device†to improve the integration of autologous red bone marrow into artificial bone graft materials with the help of external instruments.
After 7 years of scientific research and clinical trials, the research and development of bone growth accumulators has finally made breakthroughs. Studies have confirmed that it can effectively enrich autologous red bone marrow and increase the osteogenic activity of bone graft materials. In April 2013, the Department of Orthopaedics of Southwest Hospital was authorized by the National Health and Family Planning Commission to start clinical application. Up to now, there have been nearly 120 patients who need bone transplantation. Through this method, high-activity allogeneic bone suitable for their own needs is made on site in the bone graft operation, and then combined with the autologous bone to be implanted into the desired part of the body.
After more than one year of follow-up and observation, the results of these 100 patients with allogeneic bone implantation were good. The superiority of this technology has been initially confirmed.
Allogeneic bone transplantation is expected to be widely promoted
In May 2014, Dr. Hou Tianyong, one of the leaders of the “Bone Growth Enrichment†project and the Department of Orthopaedics of Southwest Hospital, published his paper in the internationally renowned academic journal Biomaterials. "Although allogeneic bone research is not fully mature and its clinical application is still very limited, it is now an indisputable fact that it can be successfully transplanted into the human body and replace some of the autologous bone function." Hou Tianyong said that allogeneic bones are for a long time. It is still impossible to replace autologous bone, but its application prospects are considerable.
It is understood that as one of the auxiliary tools for making high-activity allogeneic bone, a new generation of high-osteo-active material building device "bone growth enrichment device" that has been put into production has been gradually promoted and applied in China. Hou Tianyong said that with the deepening of research on high-activity bone repair materials, its application in the field of bone transplantation will certainly become more and more extensive in the future.
Source: Allogeneic, bone graft
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