[Viewpoint] Gene sequencing is not the road to precision medical treatment

Precision medicine is not just about genetic sequencing . The former contains more things than the latter. In fact, precision medicine emphasizes the integration of multiple omics data, and also embodies the essence of the emerging interdisciplinary "system biology" in the life sciences. Moreover, the influence of environmental factors can not be underestimated. Only by systematically grasping external environmental factors and internal genetic characteristics, the goal of precise medicine can be realized.

Most people equate to genetic sequencing when talking about precision medicine. In fact, this is just an illusion. Accurate medicine emphasizes the integration of multiple omics data. To some extent, it also reflects the essence of the emerging interdisciplinary "system biology" in the life sciences. In addition, environmental factors cannot be ignored, and the flora in the human intestines is inextricably linked to our health. The goal of precision medicine can only be achieved by systematically grasping external environmental factors and inherent genetic characteristics.

When introducing and discussing precision medicine in China, most of them only emphasize the importance of genomic sequence analysis, which gives people a kind of "genomic sequencing" is the illusion of the path of precision medicine. But in fact, the strategy of "eighteen martial arts and martial arts" is precisely advocated by precision medicine. In early 2015, when the National Institutes of Health (NIH) director Frans Collins and the former US National Cancer Institute director Harold Varmus introduced the American precision medicine program, This reads: "Project participants were asked to agree to a comprehensive biological analysis (including cell types, proteins, metabolic molecules, RNA, and DNA; genome-wide sequencing when funding permits) and behavioral analysis, and their electronics Health files are linked."

误区解读:基因组测序并非精确医学必由之路

1. System biology is the "handle" of precision medicine.

"Accurate medicine" is not the first of the US President Barack Obama. As early as 2011, the National Research Council released a related strategic research report: "Towards Precision Medicine - Building Knowledge Networks for Biomedical Research and New Disease Classification" (Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy) (hereinafter referred to as "advancing to precision medicine") clearly put forward the concept of "accurate medicine" and its core connotation.

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