Oxford Nanopore recently received a £100 million (US$126 million) investment from the pan-Asian fund GT Healthcare, in addition to existing investors Woodford Investment Management Group and IP Group. The UK-based sequencing company claims to be using its nanopore-based genome sequencing technology to change the market currently dominated by Illumina.
A spokesman for Oxford Nanopore stressed: "We are producing a sequencer that can be used on laptops or mobile phones, breaking the regular pattern of genomic analysis." Oxford Nanopore plans to use new financing for commercial operations, which means it will face A tough battle with Illumina's marketing power.
Read DNA in real time
Nanopore sequencers can read DNA in real time, which is an advantage over current short-read technology.
Traditional sequencers take hours or days to prepare samples, and the sequencing process may take three days to a week. After the sequencing ends, a large amount of data is available before the analysis can begin.
Sample preparation for nanopore sequencing is extremely simple and can be sequenced without the need for bases, polymerases, ligases, etc., and sequencing can be as long as 10,000 to 50,000 nt. The data from the nanopore sequencer is generated continuously from the beginning. If you collect enough data in the experiment, you can terminate the experiment and immediately proceed to the next experiment.
This is critical for clinical applications where speed is required. For example, nanopore sequencing technology has recently been used to investigate the origin of fungal pathogen outbreaks in UK hospitals.
The Oxford Nanopore sequencer reads DNA as it detects changes in the current caused by a single DNA base as it passes through the nanopore membrane. Recently, nanopore technology has completed the sequencing of the human genome for the first time, costing about $2,750. Until then, the technology was limited to sequencing smaller genomes, such as the genomes of bacteria, viruses, and fungi.
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