Release date: 2014-05-05
Huang Guoying, a group of pediatric hospitals affiliated to Fudan University, led a study on the largest sample size in the world. It is proposed that the baby will be able to use the “cardiac auscultation percutaneous oxygen saturation†within 24 to 72 hours after birth. Part of the neonatal severe congenital heart disease was screened. China's newborn congenital heart disease screening work ranks among the international leading level.
The world's leading academic journal, The Lancet, published this online study on neonatal congenital heart disease last Wednesday – transcutaneous oximetry combined with clinical indicators to screen for neonatal congenital heart disease. Prospective study. This is also the first time that the "Lancet" magazine has published a research article in the Chinese pediatrics since its inception in 1823.
Professor Huang Guoying's research team led a multi-center forward-looking study in 20 hospitals across the country, funded by the Ministry of Health's key clinical projects, the third round of the Shanghai Public Health System Construction Three-Year Action Plan and the National Key Basic Research Development Program. After 3 years, the "Newborn Heart Disease Screening, Diagnosis and Evaluation" project was completed, and the "Newborn Congenital Heart Disease Screening Optimization Program" was formed. The team found that in the early neonatal period (24 to 72 hours after birth), the cardiac auscultation of two indicators of percutaneous oxygen saturation was used to screen for the sensitivity of neonatal congenital heart disease (congenital heart disease requiring intervention within 1 year of age). It was 93.06% and the specificity was 97.98%.
This multi-center prospective study was recognized by international peers. The Lancet published a review article by British scholar AndrewKEwer: (1) This is the largest sample of research worldwide (129,523 newborns, Previously reported more than twice the maximum sample size; (2) demonstrated the feasibility and reliability of screening for neonatal congenital heart disease in developing countries for the first time; (3) further promoted neonatal congenital heart disease globally Screening provides important evidence-based data. This large sample of research also provides an important basis for government decision-making.
Congenital heart disease is a common disease that seriously harms children and the health of the population. It has become the most common birth defect in China. In 2013, Professor Huang Guoying's research team reported that the incidence of neonatal congenital heart disease in Shanghai was as high as 26.6 采用 by echocardiography. Among them, the incidence of severe congenital heart disease was 3.5 ‰. Severe congenital heart disease has been identified as one of the leading causes of infant and neonatal death in China. In recent years, it has been the leading cause of death among infants and children under 5 in Shanghai.
At present, the domestic routine newborn screening system includes hearing screening and partial genetic metabolic disease screening. Screening for neonatal congenital heart disease is not only conducive to early diagnosis and intervention of children with congenital heart disease, reducing the mortality and disability rate of congenital heart disease, improving prognosis; and improving the basic knowledge of congenital heart disease and improving the diagnosis of congenital heart disease among grassroots medical staff Skills and improving the social image and influence of the government's public health system construction are of great significance.
Source: Xinmin Evening News
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