Drug companies frequently encounter drug depletion

Recently, He Xiurong, the former chairman of Guizhou Hengba Pharmaceutical Co., Ltd., was very anxious: “The company has several fist medicine products based on the traditional Chinese medicine “Shandougen”, and the raw material supply is lit due to the near depletion of wild resources. 'Red light'. If you can no longer achieve large-scale planting, these high-risk drug products will face downside risks."

Shandougen, Zhonglou, wild gastrodia, white peony, a variety of wild sarcophagus, wild eucommia ulmoides, Zijinlian, etc. are the famous authentic herbs in Guizhou. However, with the accelerating development of the province's pharmaceutical industry, such authentic herbs have been overcollected and wild resources have been exhausted.

According to statistics, at present, the value of Guizhou's proprietary Chinese medicines accounts for 80% of the province's pharmaceutical industry, and pharmaceutical companies have a huge demand for raw materials for Chinese medicine. In order to ensure the supply of pharmaceutical raw materials, many local pharmaceutical companies have planted their own Chinese herbal medicines, hoping to solve this urgent need. However, due to the chaotic introduction of provenances, some medicines have poor stress resistance, unstable efficacy, and uneven quality, which can not meet the production needs of pharmaceutical companies, resulting in many drug companies falling into the edge of the current "bump drugs" production cut-off.

People in the industry believe that with the expiration of the existing product dates of most Guizhou pharmaceutical companies and the difficulty of developing new drugs, the problem of medicinal sources may endanger the sustainable development of Guizhou's national pharmaceutical industry.

In the province of medicinal herbs, she encountered "depletion of herbs."

During this period, He Xiurong, former chairman of Guizhou Hengba Pharmaceutical Co., Ltd., was very anxious. He Xiurong said that because the company has several medicinal products based on traditional Chinese medicine "Shandougen", the demand for production is very large. The annual demand is nearly 100 tons. It has been over-collected and the wild resources are close to exhaustion. In the case of planting, medicines are likely to face downlines.

According to statistics, Guizhou has 4802 kinds of Chinese herbal medicine resources. At present, 154 varieties have been incorporated into national standards, and they have become "high-quality products" for Guizhou pharmaceutical companies through industrialization. The output value of proprietary Chinese medicines accounts for 80% of the entire Guizhou pharmaceutical industry. However, with the difficult supply of some important authentic medicinal materials such as Shandougen, Zhonglou, Wild Gastrodia, Angelica, a variety of wild Dendrobium, wild Eucommia ulmoides, Zijinlian, and blood ginseng, Guizhou Drugs with authentic medicinal herbs as the gold-signature The company feels very helpless.

During the visit, the reporter discovered that several pharmaceutical companies, such as Yizhu and Jingfeng in Guizhou, were both worried about the lack of guarantees for the production of the raw material of "Heart and Brain Vascular Pills." According to statistics from the Provincial Food and Drug Administration in 2011, due to the large amount of development of the cardiovascular and cerebrovascular diseases medicine market, the province's large fruit trees and ginger resources are only less than 500 tons.

"Last year, it was very difficult for our company to acquire at a price of more than 60 yuan per kilogram. If we follow the company's future market development goals, we must strive to achieve 10 billion yuan in output value within 5 years, and a production value of 1 billion will require dozens of tons. Daguomu Jiangzi, said Xu Rong, head of the intellectual property department of Yiwei Pharmaceutical Co., Ltd., said that this year, the Provincial Department of Science and Technology has supported the planting of large fruit trees and ginger seeds in Luodian. It has now planted hundreds of thousands of plants, but it takes 8 years to produce fruit. The only concern is that when the product enters the market, it cannot produce quality and quantity of raw materials to support product development.

There are many difficulties in solving the difficult situation. The concern of Yiwei Pharmaceutical is not worrying. As early as 2009, He Xiurong started to grow Chinese herbal medicines in Meg Township, Qingzhen City. Although hundreds of rare and valuable Miao drugs were introduced, the introduction of Shandougen has not been resolved.

“Shandongdou roots mainly grow in areas such as Pingba, Ziyun, Guanling, Huishui, Luodian, etc. In the past, wild resources were used as the main resources. Later, the wild resources were almost exhausted. The farmers transplanted them from the hills or purchased other provinces. Seed breeding. However, such large-scale planting has led to degeneration of medicinal provenances, unclear sources, and medicinal herbs that are available in the drug market. The efficacy does not conform to the pharmacopoeia standards, said He Xiurong.

In recent years, in order to realize the sustainable development of Guizhou's Chinese herbal medicines, Guizhou Province has planned and laid out 50 key medicinal herbs such as Zunyi Eucommia, Dafang Tianma, Hezhang Pinellia, and Luodian Ainaxiang, although these authentic wild herbs Great progress has been made in introduction and home research, but practical problems have also arisen.

Liu Mingfang is a villager in the Bowl Factory Village of Anlexi Township, Hezhang County, Guizhou Province. In 2008, Liu Mingfang transferred 20 acres of land to plant Pinellia. In the past few years, relying on the 20 acres of Pinellia can bring nearly 100,000 yuan in income each year to the family. Exultantly, last year his family increased the size of the 10-acre Pinellia plantation, but this time it suffered a loss.

“The planting scale of Pinellia in Hezhang County is now reaching 10,000 mu. Seed and seedlings are generally exported from the provinces of Inner Mongolia. The variety is very complicated and the quality is not guaranteed. Moreover, the Pinellia three-year-old will be mature after several generations of breeding. Variability, and the adverse resistance is relatively poor, the quality of medicinal herbs grown is unstable, it is difficult to sell a good price." Liu Ming Fang said.

Faced with the difficulties faced by Guizhou's Chinese herbal medicines, Guizhou pharmaceutical companies have also been exploring ways to solve them.

In 2008, Dechangxiang began to test water for cultivation of Salvia miltiorrhiza seedlings. The company has introduced Salvia miltiorrhiza in Sichuan, Shandong, Henan, etc., to do pre-basic studies, screening for planting varieties and testing for efficacy components. Until 2012, according to the evaluation of Guizhou Pharmacopoeia Food Quality Supervision Bureau, the main data of its Danshen seedlings exceeded the Pharmacopoeia threefold.

"We want to promote large-scale provenances and there are still technical problems." Wen Gang, general manager of Guizhou Dechangxiang Chinese Medicinal Plants Co., Ltd., said that the main introduction of Shandong Salvia miltiorrhiza is at present, but the provenances are relatively messy, such as flowering. Different, different appearance and appearance, even if the timely selection of good varieties from the outside, but also through the local purification, rejuvenation process, so that the growth cycle will be longer, is not conducive to the company's sustainable supply of raw materials.

Or it will jeopardize the development of Guizhou's pharmaceutical industry. "We have a capsule product made from blood ginseng as raw material, with a sales income of 200 to 300 million yuan a year, and sales have maintained an annual growth rate of nearly 50%. Therefore, there is a large demand for raw materials. Only last year, the demand for blood ginseng reached more than 60 tons, and it is still increasing year by year. Although we are doing research on related seedlings and cultivation, it is far from being able to hydrolyze the thirst and it is very worried about the future prospects.” Wen Gang said.

In the view of Wen Gang, ensuring a stable supply of high-quality provenances depends on the fact that companies are only able to achieve success. It is necessary to form an entire industrial chain from provenance protection, plant management, and research and development to find suitable local varieties and establish species diversity. At the same time, the base will increase the collection, sorting, purification, and rejuvenation measures of traditional authentic medicinal resources to ensure the superiority, stability, and adaptability of the provenances.

According to Wei Shenghua, associate professor of the School of Pharmacy of Guiyang College of Traditional Chinese Medicine, Guizhou is focusing on cultivating 50 varieties of medicinal herbs. The authentic seeds and seedlings that can now be bred and produced by oneself are flower buds, auspicious grass, dipsacus, epimedium, and hooks. Other species such as vines and golden pebbles are needed to purchase seed seedlings from other places; white peony root, yam bean root, red radix salviae miltiorrhizae, Radix isatidis, etc. are still undergoing provenance research, and they also need to be purchased from the outside.

Wei Shenghua said that the growth cycle of medicinal herbs is generally between 1 and 8 years, and some even longer, otherwise the content of active ingredients of medicinal herbs cannot be achieved. For example, asparagus can only be excavated in 4 or 5 years. Sophora candidata can be excavated after 3 years, and the amount of industrial production is large. Before it was used wild, a large amount of excavation was carried out. The tightness has led to the depletion of medicinal resources.

In September this year, Guiyang Medicinal Botanical Garden Seedling Breeding Research Laboratory was established and put into use. And in the new field of Wudang District, construction of rare, rare medicinal herbs species research and production and demonstration bases and Baiji, Tianmen winter, Salvia, etc. as the leading species of Chinese herbal medicine variety demonstration base. At present, more than 200 mu of land has been transferred to Xinchang Township, and more than 70 acres of land have been plowed, opened, disinfected, and covered with plastic film.

After hearing this news, Hengba Pharmaceutical immediately found the botanical garden, hoping to help solve the problem of introduction of Shandougen, but it was counterproductive. "The main source of problems lies in the collection of wild resources alone. Guizhou basically cannot find the wild white peony root, asparagus, and soya bean root. Scale planting can only be cultivated by studying the way of tissue culture and rapid propagation technology, but this breeds slowly.” Zhu Hong, director of Guiyang Medicinal Botanical Garden, said that with the expiration of the deadline for most existing Guizhou pharmaceutical companies, Where it is difficult to develop new drugs, the problem of provenance may endanger the sustainable development of Guizhou's national medicine industry.

■ Development of Chinese herbal medicine industry based on the concept of industrialization “Despite the fact that the development of Chinese herbal medicine industry in our province has achieved certain results in recent years, the problems of poor protection and cultivation of wild Chinese herbal medicine resources, imperfect technological support systems, and unbalanced development of Chinese herbal medicine industry are still outstanding. This is what Yang Xiaoxiang, the chief agronomist of Guizhou Poverty Alleviation Office thinks.

Guofa No. 2 document clearly requires Guizhou Province to promote the modernization of traditional Chinese medicine, vigorously develop proprietary Chinese medicines and ethnic medicines, cultivate a group of leading enterprises, and build a number of well-known brands, providing a rare policy support for the development of the national pharmaceutical industry. Not only that, according to related forecasts, in the next 10 years, the growth rate of the international botanical drug market will remain at more than 10%.

Last year, Guizhou Province arranged a transformation and development fund for the Chinese herbal medicine industry of 100 million yuan to build a modern Chinese herbal medicine wholesale market, study new techniques for the cultivation of Chinese herbal medicines, processing of production areas, pest control and technical training, and change the current situation of Guizhou's Chinese herbal medicine industry. Let's put the current status of the business and increase the added value of medicinal materials.

Yang Xiaoxiang said that in the process of developing the Chinese herbal medicine industry in Guizhou Province, the seamless connection between the base and the workshop, the promotion of agriculture, and the development of the agricultural industry, is gradually forming a modern Chinese medicine industrial chain of “seed breeding, processing, and pharmaceutical production market sales”. The development model has explored a new approach for the cultivation and processing of Chinese herbal medicines in Guizhou.

To this end, in February last year, Guizhou Province issued the “Opinions on Perfecting the System and Mechanisms to Accelerate the Advancement of the Modernization of Traditional Chinese Medicines for the Industrialization of Chinese Medicinal Products.” It stipulates that the leadership system of “science, agriculture, industry, and business” thinking will be established to strengthen Chinese herbal medicines. Industrial scientific research, improve the quality level, develop new varieties, actively promote the construction of Chinese herbal medicine bases, promote the adjustment of agricultural structure, develop the private economy, build the brand of yaoyao medicine, and vigorously promote the development of the Chinese herbal medicine market system.

■Experts recommend strengthening seed protection and implementing improved seed project “Strengthening the protection of Chinese herbal medicine germplasm resources is the fundamental guarantee for ensuring the longevity of Chinese herbal medicine production.” Wei Shenghua, associate professor of the School of Pharmacy of Guiyang College of Traditional Chinese Medicine, said that the protection of endangered medicinal herbs should be strengthened. It is necessary to establish a germplasm conservation library to investigate the resources of rare and endangered medicinal plant materials in Guizhou Province, establish archives of rare and endangered medicinal plants in Guizhou, determine the list of key protected species, and propose evaluation criteria for the endangered status and protection level of traditional Chinese medicine resources.

At the same time, it is necessary to establish seed breeding centers and quality inspection centers for Chinese herbal medicines, accelerate the introduction, screening, demonstration, and promotion of fine new varieties at home and abroad, build germplasm resource collection nurseries, demonstration and development parks, and collect and preserve domestic and foreign excellent new varieties and Famous wild herbal resources, purification and remediation of Chinese herbal medicines. In addition, we will strengthen the research on selection and breeding of medicinal materials and develop new varieties of Chinese medicinal materials with special names, special, excellent, and dilute, such as the resistant varieties of Atractylodes macrocephala, Fritillaria spp., and the high flavone content of Chrysanthemum morifolium, so as to ensure clear lines, excellent traits, and stable composition. Cultivars.

In addition, for ethnic drugs that have industrialization basis in Guizhou, especially those with relatively small amounts of wild resources, it is necessary to carry out research on wild-variety species and artificial cultivation techniques. As for the potential of the market, it is necessary to take precautions against the biological characteristics of the species, integrate the forces of production, education and research, and promote research in scientific research institutes so as to lay a foundation for the sustainable development of Guizhou Pharmaceutical.