[China Pharmaceutical Network Technology News] can realize non-destructive testing without disassembling or destroying the assembly and stopping the operation of the equipment. It can take pictures and video recording of the parts with problems. Industrial endoscopes are used as a non-destructive test. Provides strong support for the inspection of the outer surface of the weld.
Industrial endoscopes escort the pharmaceutical equipment industry
Serious inconvenience may occur in the welding of the pipe of the pharmaceutical engineering construction pipeline. The main function of the industrial endoscope is to detect the inside of the pipe, the instrument and the inside, which are not recognized by the human eye, and mainly inspect the pipe and the surface of the weld. Whether there are cracks, white spots, blisters, pores and slag inclusions. Splashes, scales, pits, paint and rust on the weld surface of the workpiece should be eliminated before inspection. Due to the complicated environment in which industrial pipe endoscopes are used, it is usually necessary to determine the type of endoscope to be used according to the specific position and requirements of the test object. At least the position, direction, and path of the test must be considered. Complex products often require multiple models. Use with an endoscope.
Before the factory begins to manufacture products, it must ensure that the plant equipment is clean and clean to prevent unnecessary pollution. Therefore, the production is made of stainless steel, and the welding inspection of these equipment is very important. As the most widely used visual non-destructive testing tool, industrial electronic video endoscopes have been the main tool in industrial microscopy. Through the video endoscope, the quality and color of the welded joints, as well as the residue on the weld, can be observed for inspection. The inner surface of the stainless steel tube is smooth to prevent scratches on the surface of the purely electropolished polished pipe. The combination of an industrial endoscope allows intuitive identification of fine cracks on stainless steel pipe weldments.
Factory production has high requirements on pipeline quality. Although welding stainless steel is not as difficult as welding aluminum, its material has certain properties that may cause many variables. The stainless steel tube must be smooth and free of oxidation. Since the thickness of the stainless steel thin-walled tubes is less than 3 mm, the order of assembly and welding is improper, and the selection of welding process parameters is unreasonable, which may cause welding deformation of the tube sheets, resulting in poor sealing and pulling off of the tubes. As shown below:
Reasons for tube plate welding deformation: 1 improper assembly and welding sequence; 2 welding direction is incorrect; 3 welding parameters are unreasonable, causing local overheating; 4 no appropriate auxiliary measures are adopted.
Although pipe welding belongs to the same welding engineering technology as other welded structures, since the pipe connection is a typical shell structure, unlike the general beam structure and the grid structure, the pipe must withstand the pressure inside and outside the pipe, and the welded joint is required to have Good strength, compactness and toughness to ensure the safe operation of the pipeline system. However, in the process of welding pipelines, various defects will inevitably occur. Some defects are not negligible in the pipeline system, and are directly related to the quality. Surface tears, wear marks, etc. are common in medical clean pipe welding projects.
At present, Shanghai Yidil, Tianjin Novozymes (China) Biotechnology Co., Ltd., Zibo Huazhou Pharmaceutical Equipment Co., Ltd., Shanghai Haoyu Machinery Co., Ltd. and other domestic well-known enterprise products and engineering safety and quality inspection departments have adopted endoscopes. Video detection.
Clean pipelines in pharmaceutical equipment are an important part of the pharmaceutical production process and an important carrier for the transmission of various media in the pharmaceutical production process. At present, the sterile clean pipes are made of stainless steel and adopt the most advanced laser welding process.
GMP, FDA certification and pharmaceutical production processes all have extremely stringent requirements on the quality of pipe welds. For example, injection water pipelines, material pipelines, pure steam pipelines, etc., are required to provide a good medium conveying environment such as pollution-free, corrosion-resistant, and clean interior walls. This requires production companies and construction units to provide qualified products that meet the specific requirements of the pharmaceutical industry.
In the process of pharmaceutical equipment production and pipeline installation, in order to control the quality of pipelines and projects in order to provide qualified products that meet the standards, the primary key task is to provide high-quality, safe and reliable pipeline welding reports, various certification systems for pipelines. The welding quality is implemented in a reasonable and effective process management control.
To achieve the purpose of control, it is necessary to clarify the welding defects affecting the medium conveying environment and how to control these welding defects in the actual production process.
The 21 CFR 210,211 part of the United States and the FDA and EU GMP of Europe all have relevant sections on the requirements of pharmaceutical machinery equipment, pipe materials, surface roughness, and equipment piping. For example, China's GMP requirements for pipeline design and installation have Article 32: “The surface of equipment that is in direct contact with medicines should be clean, flat, easy to clean or disinfect, corrosion-resistant, and not chemically altered or adsorbed with drugs†Article 34 “Purification The preparation, storage and distribution of water and water for injection should prevent the growth and pollution of microorganisms, and the materials used in storage tanks and pipelines should be non-toxic and corrosion-resistant. The design and installation of pipelines should avoid dead angles and blind pipes.
If the above-mentioned weld defects occur in the clean pipe welds of pharmaceutical equipment, but it cannot be fully observed by the human eye or without industrial endoscopy, it will cause residual slag at the clean pipe welds after the equipment is put into operation, and the cleaning will not be complete. Clean, this will directly affect the quality of the produced drugs, and even lead to batch production of drugs unqualified, resulting in serious waste of resources, but also seriously affect the reputation of pharmaceutical equipment factories.
Industrial endoscopes escort the pharmaceutical equipment industry
Serious inconvenience may occur in the welding of the pipe of the pharmaceutical engineering construction pipeline. The main function of the industrial endoscope is to detect the inside of the pipe, the instrument and the inside, which are not recognized by the human eye, and mainly inspect the pipe and the surface of the weld. Whether there are cracks, white spots, blisters, pores and slag inclusions. Splashes, scales, pits, paint and rust on the weld surface of the workpiece should be eliminated before inspection. Due to the complicated environment in which industrial pipe endoscopes are used, it is usually necessary to determine the type of endoscope to be used according to the specific position and requirements of the test object. At least the position, direction, and path of the test must be considered. Complex products often require multiple models. Use with an endoscope.
Before the factory begins to manufacture products, it must ensure that the plant equipment is clean and clean to prevent unnecessary pollution. Therefore, the production is made of stainless steel, and the welding inspection of these equipment is very important. As the most widely used visual non-destructive testing tool, industrial electronic video endoscopes have been the main tool in industrial microscopy. Through the video endoscope, the quality and color of the welded joints, as well as the residue on the weld, can be observed for inspection. The inner surface of the stainless steel tube is smooth to prevent scratches on the surface of the purely electropolished polished pipe. The combination of an industrial endoscope allows intuitive identification of fine cracks on stainless steel pipe weldments.
Factory production has high requirements on pipeline quality. Although welding stainless steel is not as difficult as welding aluminum, its material has certain properties that may cause many variables. The stainless steel tube must be smooth and free of oxidation. Since the thickness of the stainless steel thin-walled tubes is less than 3 mm, the order of assembly and welding is improper, and the selection of welding process parameters is unreasonable, which may cause welding deformation of the tube sheets, resulting in poor sealing and pulling off of the tubes. As shown below:
Reasons for tube plate welding deformation: 1 improper assembly and welding sequence; 2 welding direction is incorrect; 3 welding parameters are unreasonable, causing local overheating; 4 no appropriate auxiliary measures are adopted.
Although pipe welding belongs to the same welding engineering technology as other welded structures, since the pipe connection is a typical shell structure, unlike the general beam structure and the grid structure, the pipe must withstand the pressure inside and outside the pipe, and the welded joint is required to have Good strength, compactness and toughness to ensure the safe operation of the pipeline system. However, in the process of welding pipelines, various defects will inevitably occur. Some defects are not negligible in the pipeline system, and are directly related to the quality. Surface tears, wear marks, etc. are common in medical clean pipe welding projects.
At present, Shanghai Yidil, Tianjin Novozymes (China) Biotechnology Co., Ltd., Zibo Huazhou Pharmaceutical Equipment Co., Ltd., Shanghai Haoyu Machinery Co., Ltd. and other domestic well-known enterprise products and engineering safety and quality inspection departments have adopted endoscopes. Video detection.
Clean pipelines in pharmaceutical equipment are an important part of the pharmaceutical production process and an important carrier for the transmission of various media in the pharmaceutical production process. At present, the sterile clean pipes are made of stainless steel and adopt the most advanced laser welding process.
GMP, FDA certification and pharmaceutical production processes all have extremely stringent requirements on the quality of pipe welds. For example, injection water pipelines, material pipelines, pure steam pipelines, etc., are required to provide a good medium conveying environment such as pollution-free, corrosion-resistant, and clean interior walls. This requires production companies and construction units to provide qualified products that meet the specific requirements of the pharmaceutical industry.
In the process of pharmaceutical equipment production and pipeline installation, in order to control the quality of pipelines and projects in order to provide qualified products that meet the standards, the primary key task is to provide high-quality, safe and reliable pipeline welding reports, various certification systems for pipelines. The welding quality is implemented in a reasonable and effective process management control.
To achieve the purpose of control, it is necessary to clarify the welding defects affecting the medium conveying environment and how to control these welding defects in the actual production process.
The 21 CFR 210,211 part of the United States and the FDA and EU GMP of Europe all have relevant sections on the requirements of pharmaceutical machinery equipment, pipe materials, surface roughness, and equipment piping. For example, China's GMP requirements for pipeline design and installation have Article 32: “The surface of equipment that is in direct contact with medicines should be clean, flat, easy to clean or disinfect, corrosion-resistant, and not chemically altered or adsorbed with drugs†Article 34 “Purification The preparation, storage and distribution of water and water for injection should prevent the growth and pollution of microorganisms, and the materials used in storage tanks and pipelines should be non-toxic and corrosion-resistant. The design and installation of pipelines should avoid dead angles and blind pipes.
If the above-mentioned weld defects occur in the clean pipe welds of pharmaceutical equipment, but it cannot be fully observed by the human eye or without industrial endoscopy, it will cause residual slag at the clean pipe welds after the equipment is put into operation, and the cleaning will not be complete. Clean, this will directly affect the quality of the produced drugs, and even lead to batch production of drugs unqualified, resulting in serious waste of resources, but also seriously affect the reputation of pharmaceutical equipment factories.
PCR ( Polymerase Chain Reaction)
It provides a way to make more copies of a portion of DNA.
We need to have PCR ingredients that include DNA portion, Buffer solution, Primer+DNA (tap polymerase), and Nucleotides during the preparation step.
In the step of PCR sequence, there are three steps in this section.
Step 1 Denaturation
The addition of heat is needed to separate the two strands of the DNA molecule.
Step 2 Annealing
Temperature, is going to be cool in this step, should allow the primers to bind to the specific segments.
Step 3 DNA Synthesis
To make more copies of the DNA.
Those three steps above keep repeating to make enough copies of the DNA fragments. It is the principle of how PCR machine works.
Superyears General 2215 RT-qPCRadopts all-in-one with an industrial art design, combining the Analytical Instrument, Large touch screen, and Computer. General 2215 RT-qPCR is equipped with the proven thermal-cooled electric technology, which can recognize the speed rate of temperature control faster and obtain high-quality testing results within 40 minutes. To ensure the sensitivity and stability of the testing a design with traditional beam path with a susceptible CMOS image sensor is used. In addition, General 2215 supports multiple PCR analysis and High-resolution Melt Curve (HRM) analysis, compatible with the mainstream reagent kit in the market. It will be the best assistant and your preferred RT-qPCR.
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