Researchers from the Seidman Cancer Center presented their new findings this week at the 57th Annual Meeting of the American Blood Association (ASH) in Orlando. In the poster exhibition, Yunus Alapan, Umut Gurkan and Jane Little showcased very promising findings on developing new technologies for early diagnosis of infant sickle cell disease. In economically underdeveloped countries, it takes too much money and time to make a timely and timely diagnosis and save lives. However, an innovative mobile biochip device, the heme chip, has the unique ability to quickly screen for sickle cell disease with just a few drops of blood.
“Although screening for neonatal sickle cells is standard in the United States, in Africa, very few infants have been screened because of the high level of skill and cost of launching traditional tests,†said UH Seidman Cancer Center, Director of the Adult Sickle Cell Anemia Center. And Dr. Little, an associate professor of the medical sciences, said. "This new mobile technology provides an easy-to-use and low-cost tool that allows us to use this mobile device to get closer to standardizing neonatal sickle cell disease screening, simplifying the diagnostic process. It can be used worldwide. The developing countries have had a huge impact, allowing the disease to be treated early."
More than half of newborns with sickle cell disease (SCD) die in their resource-constrained countries before the age of five. More than 6 million people in western and central Africa suffer from this disease, often causing pain, extensive organ damage and premature death.
Today, neonatal screening tests can only be performed in a central laboratory in a third country. It takes a few weeks for the results to come out, and it is impossible to contact the parents of the children who have left the health center. This may delay early important interventions, including immunization, antibiotics, and vitamins. Therefore, a simple, fast and mobile neonatal red blood cell type analysis device is very necessary. Through this device test, hemoglobinopathy can be diagnosed while the baby is still at the test site.
Through a small blood sample, the heme chip, a micro-electrophoresis device, can detect and identify hemoglobin, including hemoglobin disease, sickle cell anemia, sickle cell characteristics, and sickle cell disease. Using the new heme chip platform, the research team plans to go to Ghana to implement a practical screening for pediatric patients.
The heme chip was developed by Dr. Gurkan, an associate professor of aerospace mechanical engineering at Case Western Reserve University, working with a group of researchers, including Dr. Little, a member of the Case Western Reserve Cancer Center.
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