According to foreign media reports on August 29, experts have been worried for thousands of years that people have been unknowingly carrying and spreading the mad cow disease virus known as VCJD. The current research shows that the virus may spread through the blood. Very large. The researchers detected variant proteins that infect the VCJD virus in blood samples from hamsters (European rodents of a small hamster Cornea family, often raised as pets or used for experimental studies). The study was completed in just a few days, but if the same procedure was used for humans, it may be necessary to detect blood deposits in all blood banks. Therefore, the current inspection work has not yet fully started. It is reported that two patients in the UK have been killed by the VCJD virus, and they are probably due to blood loss. If this is confirmed, then not only the blood bank, but also the animals that have entered the human food chain are tested for this virus. This rare virus is thought to be caused by prions in the brain (infectious proteins, tiny protein particles, similar to the virus, but no nucleic acid, which are considered to be infectious agents of scrapie and other neurodegenerative diseases of the nervous system. ) Variation formed. These mutated proteins apparently multiply by altering the composition of the normal proteins they come in contact with, eventually leading to a fatal neurodegenerative disease. The prions are mainly concentrated in the brain, so the detection of trace amounts of prions that circulate in the blood presents a great challenge to humans. To detect whether an animal is infected with the virus, experts must first kill the animal and take its brain tissue for testing. Some scientists try to extract blood from an animal and then inject it into the brain of another animal, and then observe it. It usually takes several months to see if the injected animal is infected with the clinical features of these viruses. But the success rate of this method is only 30%, and it is not yet known whether this method can cross species testing, that is, human blood samples are injected into the hamster's brain. Claudio Teato of the University of Texas decided to take another approach to multiply the amount of mutated protein in the blood to detectable levels. Sato’s team had already completed the first step four years ago, which was to copy a large number of variant proteins from the brains of hamsters. This technique involves putting normal proteins together with a small amount of variant protein in one test tube and allowing the mutant protein to multiply in more than half an hour. The pulsed wave was then used to stop the mutant protein from reproducing to observe the situation. Through tests on 18 virus-infected hamsters and 12 healthy hamsters, the blood circulation was 140 times, and 50% of the hamsters could be found in the blood of hamsters. Sato said that testing the technology in humans may be less than six months, but it needs to be tested repeatedly before testing because ethical problems are encountered in testing on humans. After all, the virus has not yet been completely cured. method.
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