In 1895, scientists successfully isolated Xanthomonas campestris. The study of this bacterium for more than 100 years has never stopped, but no effective control measures have yet been found. The bacteria causing black rot of cruciferous vegetables can rapidly infect through the vascular bundles of plants under high-temperature and high-humidity environmental conditions, causing wilting, necrosis and rot in the leaves of plants, which can harm more than one hundred kinds of monocotyledons. And hundreds of dicotyledons grow. Today, news came from the "Genome Research" magazine that Chinese scientists have made important progress in the field of comparative genomics and functional genomics of the black rot pathogen. Xanthomonas campestris can seriously affect the yield and quality of cabbage, cabbage, broccoli, leeks, and radishes. The current prevention and control methods are mainly controlled by chemical pesticides, which can easily cause pollution. Therefore, understanding how Xanthomonas campestris infects plants will provide theoretical guidance for the control of black rot. The research group headed by the researcher He Chaozu of the Institute of Microbiology, Chinese Academy of Sciences, teamed up with the National Human Genome South Center, Guangxi University, and the National Human Genome Center North to complete a complete X. campestris genome genome sequence and use comparative genomes. Academic and functional genomics and other advanced methods systematically studied genes involved in the pathogenesis of black rot. From 16512 mutants, the study confirmed that at least 13 types of 75 genes (about 1.8% of the total genome of 4273 genes) directly or indirectly involved in the occurrence and development of the disease. The identification of these genes indicates that the pathogenic process of black rot is very complicated and requires the participation of multiple bacterial physiology and metabolic processes. The research results are published today as a cover article in the "Genomics Research", an authoritative international genomics journal. This is the first time that domestic related research work has been published in the magazine as a cover article. "Genome Research" believes that this work has carried out the largest gene mutation of pathogenic bacteria (containing animal pathogenic bacteria) and screening for pathogenic-related genes so far and highly evaluated it. The editorial department of Genome Research released the news today and introduced the research progress to the public. It is understood that this achievement provides genetic evidence and experimental materials for the in-depth analysis of the molecular mechanism of black rot. It will contribute to the research of bacterial diseases in rice and other crops in China, and will open new avenues for controlling crop diseases.
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