Release date: 2017-05-26
Pluripotent stem cells have the same properties as embryonic stem cells and can be used to make many types of tissues, including: nerve cells and heart cells.
Sina Technology News Beijing May 26 news, according to foreign media reports, at present, an innovative research by scientists can be based on the patient's skin cells to cultivate bleeding cells, the future is expected to end the blood donation era.
For the first time, scientists use embryonic stem cells to produce human blood cells, which have the ability to develop into various tissues of the human body. They use mice as living cell factories, and blood stem cells can produce four types of blood cells. This means that the matching blood type can be perfectly tailored for patients, especially those with leukemia or chemotherapy who have lost their hematopoiesis.
Dr. George Daley, a senior scientist at Boston Children's Hospital, said: "The good news is that we are about to develop benign human hematopoietic stem cells in our vessels." The latest study, published in Nature, is expected Develop personalized treatments for blood diseases while alleviating the shortage of donated blood.
Since scientists were able to isolate embryonic stem cells in 1998, researchers have rarely succeeded in using embryonic stem cells to make blood-forming hematopoietic stem cells (HSCs). In 2007, scientists used human re-synthesis to make artificially induced pluripotent stem cells (iPS), which have similar properties to embryonic stem cells and can be used to generate many types of body tissues, including nerve cells and heart cells. However, hematopoietic stem cells still have a certain mystery.
The Boston Children's Hospital team began researching embryonic stem cells and induced pluripotent stem cells and exposing them to chemical signals, causing them to transform into hematopoietic gene endothelial cells, an early embryonic tissue that eventually forms hematopoietic stem cells.
Scientists can't directly create hematopoietic stem cells, but instead "connect" the body's hematopoietic capacity, they need more genetic design, they transplant hematopoietic gene endothelial cells into mice. With the development of hematopoietic stem cells, the blood cells eventually mature in the animal body.
A few weeks later, scientists discovered that several mice carry human blood cells in their bone marrow and blood vessels. They are very interested in inducing pluripotent stem cells (iPS) to make blood cells. Most importantly, these cells can be derived from the patient's skin. Dr. Ryohichi Sugimura, co-author of the study, Boston Children's Hospital, said: "This study will open the extraction of cells from patients with genetic blood diseases, use genetic editing to correct genetic defects, and create functional blood cells. This means we can get from universal blood transfusion Extracting cells in vivo, providing hematopoietic stem cells and blood indefinitely, will potentially increase the blood supply to transfused patients."
According to a report in the journal Nature, another research team used different techniques to successfully create mouse cells resembling hematopoietic stem cells. The study was conducted by Dr. Shahin Rafii of Weill Cornell Medical College. He converted the blood vessels of the cell line into immunological hematopoietic stem cells and successfully completed development after transplantation in a layer of umbilical cord tissue. (å¶å€¾åŸŽ)
Source: Sina Technology
High Dispersion Homogenize Machine,Ultrasonic Homogenizer,Stomacher Blender,Handheld Ultrasonic Homogenizer
Guangdong Widinlsa International Co.Ltd , https://www.widinlsamachine.com