Biology Report: The researchers identified an important Chinese herbal medicine, Ginkgo biloba, as a key cellular pathway for protecting brain cells. If these results are confirmed in the human body, Ginkgo biloba may be used to reduce stroke damage. In some countries, traditional Chinese medicine uses Ginkgo biloba extract to treat asthma, bronchitis, and brain diseases.
Although many of the miraculous effects of Ginkgo biloba reported by Chinese medicine have not yet been confirmed, doctors in the United States are currently studying the effect of this herb in relieving memory loss and memory problems in Alzheimer's patients.
Sylvain Dor, of the Johns Hopkins University School of Medicine, discovered a mechanism to study how to overcome post-stroke injury. Stroke attacks can quickly kill a small area of ​​the brain, but the surrounding brain tissue can also die within the next few weeks. Dor's team found that a lack of a mouse called heme oxygenase had a very poor stroke recovery. This enzyme can convert heme into less toxic compounds, some of which also neutralize oxygen radicals. Sylvain Dor's team speculates that ginkgo may activate this enzyme and protect brain cells.
To confirm this hypothesis, they first cultured brain cells from embryonic mice, added standard ginkgo extract and examined the survival of laboratory cultured neurons under oxidative stress. As a result, it was found that the more Ginkgo biloba extracts, the more neurons make more enzymes - indicating that Ginkgo biloba can indeed activate this protective enzyme. Moreover, the high dose of Ginkgo biloba extract almost completely protected the cultured neurons from oxidative damage, whereas 60% of the cells in the control were killed. Then, the researchers also used a ginkgo or a blank solution to feed the mice for one week to induce stroke. As a result, Ginkgo biloba reduced the brain lesion area after stroke in mice by half, but it had no effect on mutant mice lacking heme oxygenase. These ginkgo-protected mice behaved normally after stroke, while unprotected mice and mice lacking heme oxygenase were abnormal in their actions. These two experiments further revealed that Ginkgo biloba was protected by opening heme oxygenase. Their researchers published their findings at the North American Supplemental and Binding Drug Research Conference.
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