Rescue of adverse reactions to cattle foot-and-mouth disease vaccine

Foot-and-mouth disease is a type of infectious disease. It has characteristics of rapid onset, rapid spread, and large damage. Vaccination is one of the important measures to prevent the occurrence of foot-and-mouth disease. In the on-site inoculation, individual cattle have different degrees of allergic reactions due to individual differences. In some cases, due to unsuccessful salvage or unsuccessful salvage methods, the death of cattle is caused and economic losses are caused to farmers. In recent years, the author has explored some effective rescue methods in clinical practice for reference and reference.

1, adverse reactions and rescue

1.1 General reactions

Individual cattle lost their spirits after a vaccine, lost milk production, lost appetite and increased body temperature. Normally, no special treatment is required and it will return to normal after 1 to 3 days.

1.2 Serious reactions

Due to individual differences, individual cows will experience acute allergic reactions after vaccination, with rapid breathing, visible mucous membrane congestion, edema, muscle tremors, rumen hernia, white foam in the mouth, and convulsions in the mouth. Death due to unsuccessful rescue.

2. Treatment measures

For the most acute type of reaction: it is recommended to rapidly subcutaneously administer 0.1 mg epinephrine hydrochloride 5 mg subcutaneously, depending on the degree of remission, after 20 minutes can be repeated injection of the same dose; intramuscular injection of promethazine hydrochloride (phenazine) 500 mg; intramuscularly Sodium secamate sodium phosphate 30 mg (not used for pregnant animals). For shocked cattle, in addition to the rapid injection of the above drugs, they must be rapidly acupunctured at the tip of the ear and large veins (on the vein at the anterior third of the vein vein groove). Tail junction between the spinous process depression), hoof head (hocks dorsal midline dorsal, hairy and hairless junction; that is, three, four hoof on the edge, each foot inside and outside the hole, a total of 8 points). Rapid establishment of intravenous access, norepinephrine 10 mg, added to 2000 ml of 10% glucose injection intravenous infusion, such as the body temperature below 36.5 °C in patients with the addition of the above drugs, plus acetyl coenzyme A1000 units, ATP (adenosine triphosphate) Infusion of 200 mg, 3000 mg of inosine, 2000 ml of 25% glucose. After the cow wakes up, after the restoration of the pulse, remove this group of drugs and replace it with 2000 ml of 5% glucose saline, add vitamin C5 g, vitamin B63000 mg, and instill, and then use 5% sodium hydrogen sulfate solution 500 ml. can.

Acute-type reaction: generally, only rapid intramuscular injection of promethazine hydrochloride (non-alkangan) 500 mg, dexamethasone sodium phosphate 30 mg (pregnancy useless), subcutaneous injection of 0.1% epinephrine hydrochloride 5 mg can be very sick Recover quickly.

3. Prevention of vaccine adverse reactions

3.1 Carefully read the instructions and carefully investigate the health status before the vaccine injection. The thin and sick animals and the maternity animals will not be injected. The standby body will be refilled after recovery.

3.2 If there has been a history of vaccine reactions, it is recommended that subcutaneous injections of 0.1% epinephrine hydrochloride and promethazine hydrochloride be administered subcutaneously before the vaccine is injected, and then the vaccine should be injected to reduce the occurrence of adverse reactions.

3.3 The above drug dose is the dose of adult cattle, and the cattle should be administered as appropriate.

In the past few years, I have used the above method to rescue 12 cattle vaccines with serious adverse reactions. All have achieved satisfactory results and none have died.

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