Release date: 2015-10-27
Image source: medicalxpress.com
Recently, in a research paper published in the international magazine Science , scientists from the German Center for Neurodegenerative Diseases have shown that the brains of young people at risk of Alzheimer's disease may be dealing with spatial navigation. There is a certain difference from normal individuals. The researchers point out that it is unclear whether this brain change is a precursor to Alzheimer's disease. The current research mechanism is still unclear, and a lot of research is needed to know.
Researcher Axmacher said that if brain differences can indeed predict that individuals will develop Alzheimer's disease later, then using relevant research information may reveal high-risk individuals; in this study, researchers were 75 Young people conduct research, in which half of the individuals carry the APOE mutation gene, which is thought to increase the risk of Alzheimer's disease in individuals.
It is estimated that 1 out of every 6 individuals carry the APOE4 mutant gene, and the carrier's risk is three times that of the non-carriers; the researchers used advanced MRI techniques to study the participants' brain olfactory cortical structure. The entorhinal cortex includes so-called grid cell cells, which are important for spatial navigation of individuals. When Alzheimer's disease occurs, the ability of individual spatial navigation is absent. The researchers then allowed participants to perform navigation tasks while recording the activity of the participants' grid cells. The results of the study showed that during the task, the carrier's grid cell function was compared to individuals who did not carry the APOE4 mutant gene. Poor.
The researchers then asked if individuals carrying the APOE4 mutation were trying to make up for the missing by navigating through other brain regions. The researchers found that the more incomplete the individual grid cells, the more active the nearby brain regions, so the APOE4 mutant gene carriers tend to show a completely different strategy in the experiment.
There are no effective therapies so far that can help inhibit Alzheimer's disease, but the research in this paper may help researchers develop new therapies, and researchers need to look for specific biomarkers for high risk in clinical trials. Detection of sick individuals.
Source: Bio Valley
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