Release date: 2016-03-23
Scientists from Switzerland have developed a new class of treatments that can treat Alzheimer's disease. This approach involves implanting a capsule-like device under the skin to counteract a class of proteins that are likely to cause disease.
These proteins are called beta-amyloid peptides, and subcutaneous capsules contain cells that specifically neutralize these proteins. By producing antibodies, these cells activate the immune system in the patient's body, thereby removing the beta-amyloid polypeptide before it is formed, thereby preventing the formation of plaque, affecting the body's cognition, memory and the like.
The technology was developed by researchers at the Federal Institute of Technology in Lausanne and has been validated at the mouse level. In the animal model of Alzheimer's disease, the implantation of this device can significantly reduce the number of amyloid plaques.
One of the advantages of the capsule is that it is only colonized under the skin of the patient and is capable of continuously producing antibodies against beta-amyloid polypeptide. Next, the researchers said the device was valid for up to 39 weeks and was able to destroy the activity of tau (another protein thought to be involved in Alzheimer's disease). The results were published in the latest issue of journal Brain.
The idea of ​​using antibodies to target beta-amyloid peptides has long existed, but existing techniques often require repeated subcutaneous injections, which can have serious negative effects. Conversely, the technology is like a quiet guard, attacking only the proteins that invade the brain.
The capsule is called a "megacapsule" and the main structure is a frame of two polypropylene membranes sandwiched between a transparent membrane. It has a length of 27 mm, a width of 1.2 mm and a thickness of 1.2 mm. The middle is filled with hydrosol to facilitate cell growth.
These cells come from the patient's immune system, through the outer permeable membrane, which absorbs the body's nutrients.
The researchers said that all the materials used to make the capsule did not cause rejection. This enables the device to be mass produced and marketed.
Source: Bio Valley
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