Pharmacological effects
1. Convergence
Pomegranate peel contains many tannins, when they are in contact with mucous membranes, wounds, etc., they can precipitate or coagulate local proteins to form a dense protective layer on the surface, helping to heal local wounds or protect local areas from irritation.
2. Antibacterial effect
The pomegranate peel decoction had antibacterial effects against Shigella in Shiga, Shishi, Fukushima and Sungai for 4 minutes. It had the strongest effect on Shiga, followed by Shi Shi and Fu Shi, and played a role in Shigella in Song Dynasty. Poor. Comparing the in vitro bactericidal activity of 400 Chinese medicines against Salmonella typhi, Vibrio cholerae, Staphylococcus, etc., proved that Pomegranate peel had the strongest effect on inhibiting Salmonella typhi. In addition, in vitro experiments have demonstrated inhibition of Mycobacterium tuberculosis, Escherichia coli, Proteus, Pseudomonas aeruginosa and other fine bacteria. The pomegranate peel decoction gavage or pomegranate skin alcohol extract intraperitoneal injection, inoculation of mice inoculated with Pseudomonas aeruginosa model in vivo test, no significant protection. The infusion of pomegranate peel (1:4) has no effect on the inhibition of Trichoderma reesei, Concentric Ranunculus and other dermatophytes. The above antibacterial effects may be related to the large amount of tannins contained.
3. Antiviral effect
Chicken embryo test showed that the dilution of pomegranate skin decoction to 1:10000-1:100,000 still has the effect of inhibiting influenza virus (type A PR8 strain). Using cell culture technology, it was confirmed that tannin is an active ingredient of pomegranate peel against genital herpes virus. Its characteristics not only inhibit the proliferation of the virus in the cells, but more importantly, it shows a strong direct killing of the virus and the role of blocking and adsorbing the cells.
4. Deworming
Pomegranate skin decoction has anthelmintic effect. Its mechanism is to act on the parasite's muscles, causing it to contract and continue to shrink, but it has the effect of repelling insects.
5. Other effects
A compound obtained from the methanol extract of pomegranate peel strongly inhibited the carbonic anhydrase activity of bovine erythrocytes, and the inhibition rate was 80.2% at 1 ug/kg and 83,3% at 10 ug/ml. The pomegranate peel is decocted to rabbits to gavage, 2 times a day. It can treat diarrhea caused by loss of physiological balance due to digestive dysfunction.
6. Toxicity
Pomegranate peel contains more tannins, which has a stimulatory effect on the gastrointestinal mucosa. The total alkali toxicity of pomegranate peel is about 25 times that of pomegranate skin. The toxicity to frogs, mice, guinea pigs, rabbits and cats is dyskinesia and respiratory paralysis. Total alkali of pomegranate peel has a temporary stimulant effect on the heart and slows down the heartbeat; it has a nicotine-like effect on autonomic nerves, 1g/kg causes a slower pulse and higher blood pressure, and a large dose makes the pulse speed up significantly; Veratrine alkali effect.
Studies have shown that the direct toxicity of hydrolysable tannins to the liver is high, and long-term large-scale application can cause central lobular necrosis, fatty liver, and cirrhosis.
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