Tablet loosening solution

Tablet loosening solution

Clicks:48 Release time:2010-3-13 14:39:11

The phenomenon that the hardness of the tablet is insufficient is called a pine piece. The causes and solutions are:

1. Inappropriate selection or insufficient amount of wetting agent or adhesive, resulting in the medical teaching of the tableting material|the breeding network contains too much fine powder; or the drug contains more fiber, the animal keratin is large in quantity, lacks viscosity and has Elasticity, resulting in loose particles, difficult to compress; or poorly viscous minerals; or loose granularity, poor fluidity, resulting in insufficient filling to produce pine flakes. It can be added by adding a dry adhesive, or alternatively a more viscous adhesive and appropriately increasing the amount of the granules.

2. The particles are too dry, the elastic deformation is large, and the pressed sheet has poor hardness. The content is not only easy to stick when pressed, but also the hardness of the tablet is reduced. Corresponding methods can be used to regulate the water content in the granules.

3, the drug contains volatile oil, fatty oil and other ingredients, easy to cause pine. If the oil is an active ingredient, it can be added with a suitable absorbent to absorb oil, or it can be made into microcapsules or clathrates. If the oil is an ineffective ingredient, it can be removed by pressing or degreasing.

4, the preparation process is not suitable, such as the temperature of the liquid is too high, so that some of the extract carbonization, reduce the viscosity; or the fineness of the extract powder is insufficient, the viscosity is reduced. New techniques should be used to improve the formulation process.

5, the pressure is too small or the speed is too fast, the compression time is too short often cause loose pieces, can increase the pressure properly, slow down the speed.

6. The difference between the length of the punch, as the punch is shortened due to wear, the pressure of the particles in the die hole is small, or the undershoot is not flexible. The insufficient filling of the particles in the die hole will also produce loose pieces, and the punch should be replaced.

7. The tablet is exposed for too long, and the moisture is inflated and loosened. Tablets should be stored and stored under dry and closed conditions.

If you want to know more about tableting , please log in to our company: ( ) or direct pharmaceutical technology department: <> consulting, our factory will provide you with more professional services.

The phenomenon that the hardness of the tablet is insufficient is called a pine piece. The causes and solutions are:

1. Inappropriate selection or insufficient amount of wetting agent or adhesive, resulting in the medical teaching of the tableting material|the breeding network contains too much fine powder; or the drug contains more fiber, the animal keratin is large in quantity, lacks viscosity and has Elasticity, resulting in loose particles, difficult to compress; or poorly viscous minerals; or loose granularity, poor fluidity, resulting in insufficient filling to produce pine flakes. It can be added by adding a dry adhesive, or alternatively a more viscous adhesive and appropriately increasing the amount of the granules.

2. The particles are too dry, the elastic deformation is large, and the pressed sheet has poor hardness. The content is not only easy to stick when pressed, but also the hardness of the tablet is reduced. Corresponding methods can be used to regulate the water content in the granules.

3, the drug contains volatile oil, fatty oil and other ingredients, easy to cause pine. If the oil is an active ingredient, it can be added with a suitable absorbent to absorb oil, or it can be made into microcapsules or clathrates. If the oil is an ineffective ingredient, it can be removed by pressing or degreasing.

4, the preparation process is not suitable, such as the temperature of the liquid is too high, so that some of the extract carbonization, reduce the viscosity; or the fineness of the extract powder is insufficient, the viscosity is reduced. New techniques should be used to improve the formulation process.

5, the pressure is too small or the speed is too fast, the compression time is too short often cause loose pieces, can increase the pressure properly, slow down the speed.

6. The difference between the length of the punch, as the punch is shortened due to wear, the pressure of the particles in the die hole is small, or the undershoot is not flexible. The insufficient filling of the particles in the die hole will also produce loose pieces, and the punch should be replaced.

7. The tablet is exposed for too long, and the moisture is inflated and loosened. Tablets should be stored and stored under dry and closed conditions.

If you want to know more about tableting , please log in to our company: ( ) or direct pharmaceutical technology department: <> consulting, our factory will provide you with more professional services.

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