Release date: 2017-03-03
The gene editing technology CRISPR/Cas9 has made new achievements. The Roslin Institute of the University of Edinburgh, which successfully cloned Dolly, recently announced that the research team of the school has once again achieved a scientific breakthrough in the “shocking worldâ€: they use this latest gene editing tool to cultivate a group that can resist the deadly "Super pig" infected with the blue-ear disease virus. Once the technology is licensed, the world's pig industry will lose billions of pounds a year. Related research is published in the latest issue of the US Public Library of Science and Pathogens.
Porcine Blue Ear Disease, also known as Porcine Reproductive and Respiratory Syndrome (PRRS), is highly contagious in pigs, and due to rapid evolution, existing vaccines are unable to effectively prevent the spread of the virus, and the pig industry worldwide is well received. Harm, only Europe suffers more than 1.5 billion euros in damage every year.
Studies have shown that the porcine blue ear virus targets immune cells such as macrophages, and a molecule called "CD163" on the surface of such cells plays a key role in driving the virus. Previously, the team also developed transgenic pigs that did not contain the entire CD163 molecule and successfully resisted the spread of PRRS virus.
In this study, Professor Roland Institute Alan Achebold led a team working with the famous British breeding company Genus to cut off a small portion of the CD163 gene associated with the infection of the blue-ear disease virus using the CRISPR/Cas9 tool. , 32 GM pigs were cultivated. Laboratory tests on these pig cells have shown that they are completely resistant to two sub-viruses that cause PRRS disease, thereby preventing infection and spread. Next, they will continue to study the anti-infective ability of these pigs exposed to the virus.
Archerbold said that partial resection, rather than total excision of CD163 molecules, not only enhances the ability to resist blue-ear disease, but also does not affect other functions associated with CD163 molecules. “CRISPR/Cas9 is used in the breeding industry to improve food safety by reducing disease transmission and to reduce the burden on agricultural people to cope with infectious diseases.â€
This is a study that both surprises people and feels "suddenly". After all, gene editing technology has been associated with the words “improvement†and “customization†since its inception. Moreover, it has been used in the field of modern agricultural science and technology, and it has performed well, bringing more possibilities for cultivating new varieties. Thanks to advances in molecular biology, people have already known the role of CD163 molecules in this virus infection, and then a weapon called the "scissors", "two brothers" can finally be immune to viral infection. This is the gospel of the farmers and one of the gifts that gene editors bring to the world.
Source: China Science and Technology Network - Technology Daily
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