Tattoo-type sensors are more "intimate". The elastic biosensor for monitoring vital signs is expected to be on the market.

Release date: 2015-07-29

Elastic stretchable electronic components can be applied directly to the skin. Not only that, but it also measures vital vital signs such as respiratory rate, heart rate, brain wave activity, body temperature, blood oxygen levels, etc., providing data for real-time monitoring of the physical conditions of concern. More specifically, they are becoming more and more invisible, such as "bio-sticking", "tattoo" sensors, flexible devices for measuring skin thermal performance, and "smart insulin stickers", just like temporary tattoos, making people feel more fit, More intimate, it is getting more and more applications.

"Bio Stick" can sense vital signs

In 2013, MC10, the Cambridge School District of the United States, released the world's first electronic product that fits well with the body. It is specially tailored for athletes. It is called Checklight and can sense the cap and The pressure between the heads.

Now, the company is developing a flexible, sticker-like sensor called Biostamp that is said to detect brain, muscle and heart data. The details and application of this product are still unknown, but the company's founder and technical director Luz Bohe Hafarri said: "The bio-sticker used in medical treatment is expected to be listed this year."

MC10 is working with biopharmaceutical companies UCB and the University of Rochester to develop a "bio-stick" that can help patients with motor and neurological diseases. The company has also worked with Korean researchers to develop another sensor bandage sticker. It can help patients with Parkinson's disease to receive appropriate doses by detecting the degree of tremor.

John Rogers, another founder of MC10 and a professor at Illinois State University, said in the journal Science in 2014 that the principles of these bio-stickers are based on skin-friendly sensors and wireless transmission. In addition, unlike MC10's research focus, the lab named after John Rogers is working on a "bio-sticker" that allows researchers to wirelessly monitor human sleep patterns or check newborns in intensive care units.

"Tattoo" sensor can measure blood index

At Northeastern University, Associate Professor Heather Clark invented a “tattoo” sensor that can be injected into the skin to monitor five indicators commonly found in sodium, glucose, and other blood tests. This "tattoo" contains a micro-sensor that can fluoresce. With the IPhone with the app set, the fluorescence level can be measured according to the photo, and then the blood index can be understood.

In addition, the research team has developed another "tattoo" sensor that monitors lithium levels and can be used to treat bipolar disorder. It helps doctors determine the right dose of medication for each patient. So far, the team has been able to monitor the lithium content in the body of mice.

Clark said that although these devices have not yet entered human testing, the lab is looking for suitable partners to start clinical trials.

Flexible electronic device insight into skin performance

Gu Yifu Bailuqi, global vice president of cosmetics giant L'Oreal Technology Incubator, said that L'Oreal may not seem to have a breakthrough in the electronics field, but the company is interested in using thin, flexible and scalable equipment to track The skin changes brought about by the passage of time. Cosmetic manufacturers have begun using such devices to measure age-related skin thermal performance.

Although these flexible electronic devices are now only being tested, one day L'Oreal can turn it into a commercial product that helps people learn and understand their skin more. Bai Luqi and other researchers published an article in the 2015 Public Library of Science, PLOS ONE, describing this flexible electronic device for detecting skin thermal performance.

"Smart insulin paste" can monitor blood sugar

Just in June of this year, researchers at North Carolina State University created “smart insulin pastes.” In a coin-less space, there are more than 100 tiny needles containing insulin. When blood sugar levels are too high, it can sense and Quickly release insulin. The researchers found that the smart stickers lasted for up to 9 hours and they hope to continue to develop enhanced painless smart stickers that last for several days in the human body, but they have not yet entered the clinic. experiment.

In addition, in San Diego, Joseph Wang's team is working on a "tattoo" that measures blood sugar, which makes it easier for people with diabetes to live. In fact, the idea of ​​continuously monitoring blood sugar is not new. A product called a watch-type blood glucose meter has been approved by the regulatory authorities, but in 2001 it was eventually discontinued due to skin irritation. To prevent this irritation, the researchers covered the gel on the electronics.

Wang said that the new integrated electronic device that his team is developing has made some progress, but it is not clear whether it can change the bad impression brought by the watch-type blood glucose meter in the past. In addition, the research team recently demonstrated how to use a pen filled with ink to react with glucose and other chemicals to generate sensors directly on the body. The related description was published in the February issue of Advanced Medical Materials.

So far, the vast majority of "tattoos" are still in the prototype stage of the initial concept experiment, and the products that have actually entered the market have not yet appeared. The first thing that is expected to be listed will be the "bio-sticker" of MC10.

Source: China Science and Technology Network - Technology Daily

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